Development of absorption enhancer for biological drug by regulating tight junction barrier
نویسندگان
چکیده
منابع مشابه
Transmembrane proteins in the tight junction barrier.
Three types of transmembrane proteins have been identified within the tight junction, but it remains to be determined how they provide the molecular basis for regulating the paracellular permeability for water, solutes, and immune cells. Several of these proteins localize specifically within the continuous cell-to-cell contacts of the tight junction. One of these, occludin, is a cell adhesion m...
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T H~ tight junction, or zonula occludens, is an organeile of crucial importance to the development and function of most organ systems in vertebrates because it enables epithelia and endothelia to create eompositionaily distinct fluid compartments. The tight junction forms a continuous permeability barrier between adjacent cells that regulates the flux of molecules through the paracellular space...
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PLEKHA7 is a recently identified protein of the epithelial zonula adhaerens (ZA), and is part of a protein complex that stabilizes the ZA, by linking it to microtubules. Since the ZA is important in the assembly and disassembly of tight junctions (TJ), we asked whether PLEKHA7 is involved in modulating epithelial TJ barrier function. We generated clonal MDCK cell lines in which one of four diff...
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Cytokines play a crucial role in the modulation of inflammatory response in the gastrointestinal tract. Pro-inflammatory cytokines including tumor necrosis factor-alpha, interferon-gamma, interleukin-1beta?IL-1beta?, and interleukin-12 are essential in mediating the inflammatory response, while anti-inflammatory cytokines including interleukin-10 and transforming growth factor-beta are importan...
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A defective intestinal epithelial tight junction (TJ) barrier has been proposed as an important pathogenic factor contributing to the intestinal inflammation of Crohn's disease. Glucocorticoids are first-line therapeutic agents for the treatment of moderate to severe Crohn's disease. Glucocorticoid treatment has been shown to induce retightening of the intestinal TJ barrier defect in Crohn's di...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2017
ISSN: 0913-5006,1881-2732
DOI: 10.2745/dds.32.224